Global Metabolic Profiles in a Non-human Primate model of Maternal Immune Activation: implications for neurodevelopmental disorders. Boktor J, Adame MD, Rose DR, Schumann CM, Murray KD, Bauman MD, Careaga M, Mazmanian SK, Ashwood P, Needham BD. Molecular Psychiatry.(2022).
A gut bacterial metabolite modulates brain activity and anxiety-like behavior in mice. Needham BD, Funabashi M, Adame MD, Wang Z, Boktor JC, Haney J, Wu WL, Ladinsky MS, Rabut C, Hwang S, Guo Y, Zhu Q, Griffiths JA, Knight R, Shapiro MG, Bjorkman PJ, Geschwind DH, Holschneider DP, Fischbach MA, Mazmanian SK. Nature. (2022).
Plasma and Fecal Metabolites in Autism Spectrum Disorder. Needham BD, Adame MD, Serena G, Rose DR, Preston GM, Conrad MC, Campbell AS, Donabedian DH, Fasano A, Ashwood P, Mazmanian SK. Bio. Psychiatry. (2020).
Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial. Campbell AS*, Needham BD*, Meyer CR*, Tan J, Conrad M, Preston GM, Donabadian DH, Bolognani F, Rao S, Heussler H, Griffith R, Guastella A, Mazmanian SK. Nat. Medicine. (2022). *co-first authors.
Microbiota regulate social behavior via stress response neurons in the brain. Wu W-L. Adame MD, Liou C-W, Barlow J, Lai T, Sharon G, Schretter C, Needham BD, Wang M, Tang W, Ousey J, Lin Y-Y, Yao T-H, Abdel-Haq R, Beadle K, Gradinaru V, Ismagilov R, Mazmanian SK. Nature. (2021).
Gut microbial molecules in behavioural and neurodegenerative conditions. Needham BD, Kaddurah-Daouk, R, Mazmanian SK. Nature Rev. Neuro. (2020).
A gut bacterial amyloid promotes a-synuclein aggregation and motor impairment in mice. Sampson TR, Challis C, Jain N, Moiseyenko A, Ladinksy MS, Shastri GG, Thron T, Needham BD, Horvath I, Debelius JW, Janssen S, Knight R, Wittung-Stafshede P, Gradinaru V, Chapman M, Mazmanian SK. Elife. (2020).
Searching for the gut microbial contributing factors to social behavior in rodent models of autism spectrum disorder. Needham BD, Tang W, Wu WL. Dev. Neurobiology. (2018).
Controlled Measurement and Comparative Analysis of Cellular Components in E. coli Reveals Broad Regulatory Changes in Response to Glucose Starvation. Houser JR, Barnhart C, Boutz DR, Carroll SM, Dasgupta A, Michener JK, Needham BD, et al. Plos Comp. Biology. (2015).
Top-Down Strategies for the Structural Elucidation of Intact Gram-negative Bacterial Endotoxins. O'Brien JP, Needham BD, Brown DB, Trent MS, Brodbelt JS. Chem. Sci. (2014).
193 nm Ultraviolet Photodissociation Mass Spectrometry for the Structural Elucidation of Lipid A Compounds in Complex Mixtures. O'Brien JP, Needham BD, Henderson JC, Nowicki EM, Trent MS, Brodbelt JS. Anal. Chem. (2014).
Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis. Needham BD, Trent MS. Nature Rev. Micro. Invited review, (2013).
The Vps/VacJ (Mla) ABC Transporter is required for intercellular spread of Shigella flexneri. Carpenter CD, Cooley BJ, Needham BD, Fisher CR, Trent MS, Gordon V, Payne SM. Infect. Immun. (2014).
Modulating the innate immune response by combinatorial engineering of endotoxin. Needham BD, Carroll SM, Giles DK, Georgiou G, Whiteley M, Trent MS. PNAS. 110, 1464-1469 (2013).
Virulence and stress-related periplasmic protein (VisP) in bacterial/host associations. Moreira CG, Herrera CM, Needham BD, Parker CT, Libby SJ, Fang FC, Trent MS, Sperandio V. PNAS. 110, 1470-1475 (2013).
The outer membrane of gram-negative bacteria: lipid a isolation and characterization. Hankins JV, Madsen JA, Needham BD, Brodbelt JS, & Trent MS. Methods in molecular biology 966, 239-258 (2013).
The Pseudomonas aeruginosa PhoP-PhoQ two-component regulatory system is induced upon interaction with epithelial cells and controls cytotoxicity and inflammation. Gellatly SL, Needham B, Madera L, Trent MS, & Hancock RE. Infection and immunity80, 3122-3131 (2012).